PathwayStep1618 PathwayStep1640 PathwayStep1635 PathwayStep1636 PathwayStep1639 PathwayStep1637 PathwayStep1638 Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone DHA isomerizes to 4-Androstene3,17-dione Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione Reduction of androstenedione to testosterone Testosterone is converted to 5-alpha-dihydroxytestosterone Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone Androgen biosynthesis Androgens are the determining factors for male development and behaviour in vertebrates (Miller 2002). Authored: Jassal, B, 2008-10-01 13:18:42 Edited: Jassal, B, 2007-04-20 21:09:56 GENE ONTOLOGYGO:0006702 Pubmed12428201 Reactome Database ID Release 43193048 Reactome, http://www.reactome.org ReactomeREACT_11059 Reviewed: D'Eustachio, P, 2007-04-20 21:11:21