fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 Authored: D'Eustachio, P, 2005-02-08 22:51:14 Edited: D'Eustachio, P, 0000-00-00 00:00:00 Plasminogen activator inhibitor 1, a serpin, binds to fibrin-associated tissue plasminogen activator. The resulting stable complex remains associated with fibrin but cannot activate plasminogen (Wagner et al. 1989). The importance of this step in the regulation of clot dissolution in vivo is indicated by the occurence of thrombosis in individuals with abnormally little tissue plasminogen activator or abnormally much plasminogen activator inhibitor (Juhan-Vague et al. 1987). Pubmed2503541 Pubmed3109059 Reactome Database ID Release 43158795 Reactome, http://www.reactome.org ReactomeREACT_427