PathwayStep1800 PathwayStep1801 PathwayStep1802 PathwayStep1793 PathwayStep1792 PathwayStep1797 PathwayStep1796 PathwayStep1795 PathwayStep1794 PathwayStep1799 PathwayStep1798 PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane PI4KB binds to ARF1/3:GTP at the Golgi membrane PI is phosphorylated to PI4P by PI4KB at the Golgi membrane PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane Synthesis of PIPs at the Golgi membrane At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) is primarily generated from phosphorylation of phosphatidylinositol (PI). Other phosphoinositides are also generated by the action of various kinases and phosphatases such as: phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Godi et al. 1999, Minogue et al. 2001, Rohde et al. 2003, Sbrissa et al. 2007, Sbrissa et al. 2008, Domin et al. 2000, Arcaro et al. 2000). Authored: Williams, MG, 2011-10-18 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0006661 Pubmed10559940 Pubmed10766823 Pubmed10805725 Pubmed11279162 Pubmed14527956 Pubmed17556371 Pubmed18950639 Reactome Database ID Release 431660514 Reactome, http://www.reactome.org ReactomeREACT_120836 Reviewed: Wakelam, Michael, 2012-05-14