PathwayStep1783 PathwayStep1780 PathwayStep1782 PathwayStep1781 PathwayStep1776 PathwayStep1777 PathwayStep1778 PathwayStep1779 PathwayStep1772 PathwayStep1773 PathwayStep1774 PathwayStep1775 MLCL is hydrolyzed to DLCL by PLA2G4A (IM) CL transports from the ER to the IM CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) MLCL is acylated to CL by HADH (IM) MLCL transports from the IM to the ER MLCL is acylated to CL by LCLAT1 (ER) CL is hydrolyzed to MLCL by PLA2G6 (IM) MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible) CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible) DLCL transports from the IM to the ER DLCL is acylated to MLCL by LCLAT1 (ER) Acyl chain remodeling of CL Acyl chain remodeling of cardiolipin (CL) occurs in the inner mitochondria membranes (IM) via hydrolysis by phopholipases and subsequent reacylation by acyltransferases. At the endoplasmic reticulum (ER) membrane the situation is more complicated with monolysocardiolipin (MLCL) involved in hydrolysis and subsequent reacylation back to CL (Zachman et al. 2010, Malhotra et al. 2009, Xu et al. 2003, Taylor & Hatch 2009, Cao et al. 2004, Zhao et al. 2009, Buckland et al. 1998). Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0035965 Pubmed14551214 Pubmed15152008 Pubmed19075029 Pubmed19416660 Pubmed19737925 Pubmed19741254 Pubmed9487141 Reactome Database ID Release 431482798 Reactome, http://www.reactome.org ReactomeREACT_121006