PathwayStep1763 PathwayStep1764 PathwayStep1761 PathwayStep1762 PathwayStep1767 PathwayStep1768 PathwayStep1765 PathwayStep1766 PathwayStep1760 PathwayStep1759 PG is hydrolyzed to 1-acyl LPG by PLA2[1] PG is hydrolyzed to 1-acyl LPG by PLA2[16] 2-acyl LPG is acylated to PG by CRLS1 (IM) 1-acyl LPG is acylated to PG by LPGAT PG is hydrolyzed to 2-acyl LPG by PLA2[14] PG is hydrolyzed to 1-acyl LPG by PLA2G2A 1-acyl LPG is acylated to PG by CRLS1 (IM) PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM) 2-acyl LPG is acylated to PG by LPGAT PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM) Acyl chain remodelling of PG Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0036148 In the acyl chain remodelling pathway (Lands cycle), phosphatidylglycerol (PG) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane. The events occur additionally in the inner mitochondria membranes (IM) as well as in the endoplasmic reticulum (ER) membrane (Ghomashchi et al. 2010, Singer et al. 2002, Cao et al. 2008, Yang et al. 2004, Nie et al. 2010). Pubmed12359733 Pubmed15485873 Pubmed18458083 Pubmed20025994 Pubmed20705608 Reactome Database ID Release 431482925 Reactome, http://www.reactome.org ReactomeREACT_121324