PathwayStep1750 PathwayStep1751 PathwayStep1746 PathwayStep1749 PathwayStep1748 PathwayStep1747 1-acyl LPI is acylated to PI by MBOAT7 PI is hydrolyzed to 2-acyl LPI by PLA2[13] 2-acyl LPI is acylated to PI by MBOAT7 PI is hydrolyzed to 1-acyl LPI by PLA2[15] PI is hydrolyzed to 1-acyl LPI by PLA2[12] PI is hydrolyzed to 1-acyl LPI by PLA2[11] Acyl chain remodelling of PI Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0036149 In the acyl chain remodelling pathway (Lands cycle), phosphatidylinositol (PI) is hydrolyzed by phospholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid composition of glycerophospholipids to generate diverse molecules asymmetrically distributed in the cell membrane (Ghomashchi et al. 2010, Singer et al. 2002, Gijon et al. 2008, Lee et al. 2008). Pubmed12359733 Pubmed18094042 Pubmed18772128 Pubmed20705608 Reactome Database ID Release 431482922 Reactome, http://www.reactome.org ReactomeREACT_120722 Reviewed: Wakelam, Michael, 2012-05-14