PathwayStep1753 PathwayStep1754 PathwayStep1755 PathwayStep1756 PathwayStep1757 CDP-DAG is converted to PGP by PGS1 PA is converted to CDP-DAG by CDS2 PGP is dephosphorylated to PG by an unknown phosphatase PC is transphosphatidylated to PG by PLD1-4/6 PA transports from the outer to the inner mitochondrial membrane Synthesis of PG Authored: Williams, MG, 2011-09-14 Edited: Williams, MG, 2011-08-12 GENE ONTOLOGYGO:0006655 Phosphatidylglycerol (PG) is synthesised at the inner mitochondrial (IM) membrane, phosphatidic acid (PA) and cytidine triphosphate (CTP) are converted into cytidine diphosphate-diacylglycerol (CDP-DAG), which in turn is converted with glycerol-3-phosphate (G3P) into phosphatidylglycerophosphate (PGP) and cytidine monophosphate (CMP). Finally, PGP is dephosphorylated to PG. In addition, PG can be synthesised at the endoplamic reticulum (ER) membrane when phospholipase D transphosphatidylates phosphatidylcholine (PC) with glycerol to displace choline (Cho) and form PG (Piazza & Marmer 2007, Stuhne-Sekalec et al. 1986, Lykidis et al. 1997, Cao & Hatch 1994). Pubmed3718705 Pubmed7968268 Pubmed9407135 Reactome Database ID Release 431483148 Reactome, http://www.reactome.org ReactomeREACT_121280