PathwayStep1330 PathwayStep1331 PathwayStep1333 PathwayStep1332 PathwayStep1335 PathwayStep1334 Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Authored: Gillespie, ME, 2003-10-25 00:00:00 Edited: Gillespie, ME, 0000-00-00 00:00:00 GENE ONTOLOGYGO:0006635 ISBN0079130356 Pubmed12397064 Reactome Database ID Release 4377288 Reactome, http://www.reactome.org ReactomeREACT_160 The complete beta-oxidation spiral produces and consumes intermediates with a trans configuration. Mitochondrial beta-oxidation of unsaturated fatty acids leads to intermediates not compatible with the four enzymatic steps responsible for the beta-oxidation of saturated fatty acids. Unsaturated fatty acids that have bonds in the cis configuration require three separate enzymatic steps to prepare these molecules for the beta-oxidation pathway. The further processing of these intermediates requires additional enzymes, depending on the position of the double bonds in the original fatty acids. Described here is the beta-oxidation of linoleoyl-CoA.