PathwayStep1303 PathwayStep1300 PathwayStep1301 PathwayStep1302 (S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H 3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2 trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA Beta oxidation of myristoyl-CoA to lauroyl-CoA Authored: Gillespie, ME, 2003-09-19 00:00:00 Edited: Gillespie, ME, 0000-00-00 00:00:00 ISBN0079130356 Reactome Database ID Release 4377285 Reactome, http://www.reactome.org ReactomeREACT_2108 The second pass through the beta-oxidation spiral starts with the saturated fatty acid myristoyl-CoA (from the first swing through the beta oxidation spiral) and produces lauroyl-CoA. Four enzymatic steps are required starting with LCAD CoA dehydrogenase (Long Chain) activity, followed by three enzymatic steps, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and ketoacyl-CoA thiolase activities, all present in the mitochondrial membrane associated trifunctional protein.