kininogen:C1q binding protein tetramer C1q binding protein tetramer kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer Authored: D'Eustachio, P, 2005-01-20 14:44:36 Edited: D'Eustachio, P, 0000-00-00 00:00:00 Kininogen (high molecular weight kininogen; HK) associates with C1q binding protein on the cell surface in a reaction dependent on Zn++ (Joseph et al. 1996). In the body, the Zn++ needed to drive this reaction may be provided locally by Zn++ release from activated platelets (Mahdi et al. 2002). The C1q binding protein is inferred to form tetramers based on the properties of purified recombinant protein in vitro (Ghebrehiwet et al. 1994); the stoichiometry of the cell surface complex has not been determined directly. Pubmed11986212 Pubmed500690 Pubmed8195709 Pubmed8710908 Reactome Database ID Release 43158354 Reactome, http://www.reactome.org ReactomeREACT_2239