PathwayStep1607 PathwayStep1598 Recycling of bile acids and salts Bile acid and bile salt metabolism Authored: Jassal, B, 2007-01-19 10:34:59 Edited: D'Eustachio, P, 2007-04-30 14:43:26 GENE ONTOLOGYGO:0008206 In a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. Newly synthesized bile salts are secreted into the bile and released into the small intestine where they emulsify dietary fats (Russell 2003). About 95% of the bile salts in the intestine are recovered and returned to the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol to 7alpha-hydroxycholesterol. Bile salt synthesis can also begin with the synthesis of an oxysterol - 24-hydroxycholesterol or 27-hydroxycholesterol. In the body, the initial steps of these two pathways occur in extrahepatic tissues, generating intermediates that are transported to the liver and converted to bile salts via the 7alpha-hydroxycholesterol pathway. These extrahepatic pathways contribute little to the total synthesis of bile salts, but are thought to play important roles in extrahepatic cholesterol homeostasis (Javitt 2002). Pubmed11969205 Pubmed12543708 Pubmed12663868 Pubmed14699511 Reactome Database ID Release 43194068 Reactome, http://www.reactome.org ReactomeREACT_11040 Reviewed: D'Eustachio, P, 2007-04-30 14:43:26 Synthesis of bile acids and bile salts