factor VIII:von Willebrand factor multimer factor VIIIa von Willibrand factor multimer factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer Authored: D'Eustachio, P, 2005-01-20 14:44:36 EC Number: 3.4.21 Edited: D'Eustachio, P, 0000-00-00 00:00:00 Factor VIII complexed to von Willibrand factor in the blood is cleaved into several smaller polypeptides that remain associated. The acidic polypeptide on the aminoterminal side of the A3 domain of the light chain is released, however, and as this polypeptide mediates the association of factor VIII with von Willibrand factor, the activated factor VIII is released. While several proteases are capable of catalyzing these cleavages in vitro, only thrombin is active on factor VIII:von Willibrand factor complexes under physiological conditions (Eaton et al. 1986; Hill-Eubanks et al. 1989; Lollar et al. 1988; Pieters et al. 1989) Pubmed2502206 Pubmed2505252 Pubmed3082357 Pubmed3134349 Reactome Database ID Release 43158137 Reactome, http://www.reactome.org ReactomeREACT_217