PathwayStep1502 PathwayStep1501 PathwayStep1504 PathwayStep1503 PathwayStep1500 PathwayStep1509 PathwayStep1506 PathwayStep1505 PathwayStep1508 PathwayStep1507 PathwayStep1510 PathwayStep1511 PathwayStep1497 PathwayStep1498 PathwayStep1499 PathwayStep1488 PathwayStep1489 PathwayStep1486 PathwayStep1487 PathwayStep1492 PathwayStep1491 PathwayStep1490 PathwayStep1496 PathwayStep1495 PathwayStep1494 PathwayStep1493 PathwayStep1475 PathwayStep1476 PathwayStep1477 PathwayStep1478 PathwayStep1479 PathwayStep1481 PathwayStep1480 PathwayStep1483 PathwayStep1482 PathwayStep1485 PathwayStep1484 PathwayStep1356 PathwayStep1379 PathwayStep1383 SREBP1A/1C Binds the FASN Promoter SREBP1A/1C Binds the GPAM Promoter SREBP1A/1C/2 Binds the TM7SF2 Promoter SREBP1A/1C Binds the ACACB Promoter SREBF1A/1C Binds the ACACA Promoter SREBP1A/2 Binds the SQLE Promoter SREBP1A/1C/2 Binds the FDFT1 Promoter SREBP1A/1C/2 Binds the HMGCS1 Promoter SREBP1A/1C/2 Binds the FDPS Promoter SREBP1A/1C/2 Binds the ELOVL6 Promoter Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2) Expression of Diphosphomevalonate Decarboxylase (MVD) Expression of 7-Dehydrocholesterol Reductase (DHCR7) Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) Expression of ELOVL6 SREBP1A/2 Binds the MVD Promoter SREBP1A/2 Binds the LSS Promoter SREBP1A/2 Binds the SC5DL Promoter SREBP1A/2 Binds the HMGCR Promoter SREBP1A/2 Binds the CYP51A1 Promoter SREBP1A/2 Binds the DHCR7 Promoter SREBP1A/2 Binds the GGPS1 Promoter SREBP1A/2 Binds the IDI1 Promoter SREBP1A/2 Binds the MVK Promoter SREBP1A/2 Binds the PMVK Promoter Expression of TM7SF2 Expression of Squalene Monooxygenase (SQLE) Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT) Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1) Expression of Lanosterol Demethylase (CYP51A1) Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) Expression of Fatty Acid Synthase (FASN) Expression of Farnesyl Diphosphate Synthase (FDPS) Expression of Lanosterol Synthase (LSS) Expression of Lathosterol Oxidase (SC5D, SC5DL) Expression of Mevalonate Kinase (MVK) Expression of Phosphomevalonate Kinase (PMVK) Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) Activation of Gene Expression by SREBP (SREBF) After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998). Authored: May, B, 2012-07-26 Edited: May, B, 2012-07-26 Pubmed15457548 Pubmed15589694 Pubmed9748295 Reactome Database ID Release 432426168 Reactome, http://www.reactome.org ReactomeREACT_147904 Reviewed: Liang, Guosheng, 2012-08-25