PathwayStep1553 PathwayStep1595 PathwayStep1582 PathwayStep1596 PathwayStep1597 25-hydroxycholesterol is 7alpha-hydroxylated by CYP7B1 Cholesterol is hydroxylated to 25-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts Authored: Jassal, B, 2007-01-19 10:34:59 Edited: D'Eustachio, P, 2007-02-17 19:40:28 GENE ONTOLOGYGO:0006699 In a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily (Russell 2003). The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol to 7alpha-hydroxycholesterol. Bile salt synthesis can also begin with the synthesis of an oxysterol - 24-hydroxycholesterol or 27-hydroxycholesterol. In the body, the initial steps of these two pathways occur in extrahepatic tissues, generating intermediates that are transported to the liver and converted to bile salts via the 7alpha-hydroxycholesterol pathway. These extrahepatic pathways contribute little to the total synthesis of bile salts, but are thought to play important roles in cholesterol homeostasis (Javitt 2002). Pubmed11969205 Pubmed12543708 Reactome Database ID Release 43192105 Reactome, http://www.reactome.org ReactomeREACT_11054 Reviewed: D'Eustachio, P, 2007-04-30 14:43:26