Plasma kallikrein kallikrein:C1Inh kallikrein + C1Inh -> kallikrein:C1Inh Activated kallikrein binds to C1Inh (plasma protease C1 inhibitor) (Bock et al. 1986), forming a stable and enzymatically inactive complex. This reaction appears to be the major means by which kallikrein is inactivated (kallikrein can also be inactivated by binding to alpha2-macroglobulin) (Harpel et al. 1985; Ratnoff et al. 1969). Authored: D'Eustachio, P, 2005-01-20 14:44:36 Edited: D'Eustachio, P, 0000-00-00 00:00:00 Pubmed2579948 Pubmed3756141 Pubmed4178758 Reactome Database ID Release 43158399 Reactome, http://www.reactome.org ReactomeREACT_1486