PathwayStep1434 PathwayStep1436 PathwayStep1435 isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane NADPH regeneration Authored: D'Eustachio, P, 2009-01-07 23:39:54 Edited: D'Eustachio, P, 2009-01-07 23:39:54 GENE ONTOLOGYGO:0006740 Pubmed10521434 Reactome Database ID Release 43389542 Reactome, http://www.reactome.org ReactomeREACT_16904 Reviewed: Jassal, B, 2009-02-27 15:21:18 The conversion of isocitrate to 2-oxoglutarate (alpha-ketoglutarate) with the concomitant synthesis of NADPH from NADP+ is thought to play a significant role in supplying NADPH for other reactions in both the cytosol and the peroxisome (Geisbrecht and Gould 1999).