PathwayStep1424 PathwayStep1425 PathwayStep1420 PathwayStep1421 PathwayStep1422 PathwayStep1423 PathwayStep1416 PathwayStep1417 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA acetyl-CoA + H2O => acetate + CoASH acetyl-CoA + carnitine => acetylcarnitine + CoASH trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA 3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+ Peroxisomal uptake of very long-chain fatty acyl CoA hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2 tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA Beta-oxidation of very long chain fatty acids Authored: D'Eustachio, P, 2009-03-16 18:50:14 Edited: D'Eustachio, P, 2009-03-18 13:33:40 GENE ONTOLOGYGO:0033540 Linear fatty acids containing more than 18 carbons are broken down by beta-oxidation in peroxisomes to yield acetyl-CoA and medium chain-length fatty acyl CoA's such as octanoyl-CoA (Wanders and Waterham 2006). Pubmed16756494 Reactome Database ID Release 43390247 Reactome, http://www.reactome.org ReactomeREACT_17062 Reviewed: Jassal, B, 2009-02-27 15:21:18