PathwayStep1432 PathwayStep1431 PathwayStep1430 PathwayStep1427 PathwayStep1428 PathwayStep1429 palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2] palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol Conversion of acylated DHAP to lysophosphatidic acid acid palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1] Plasmalogen biosynthesis 1-Acylglycerol-3-phosphate is synthesized from dihydroxyacetone phosphate, an acyl CoA molecule and NADPH + H+ in four reactions catalyzed by peroxisomal enzymes, either in the matrix of the organelle or associated with its membrane. These reactions are annotated here for palmityl (C16:0) CoA. In a series of less well-characterized reactions in the cytosol and endoplasmic reticulum, these molecules are converted to ether lipids (plasmalogens). The functions of plasmalogens are not well understood. They are an abundant subclass of phospholipids, however, and defects in their metabolism are associated with serious human disease (de Vet et al. 1999; Nagan and Zoeller 2001). Authored: D'Eustachio, P, 2009-02-11 15:12:47 Edited: D'Eustachio, P, 2009-03-18 13:33:40 GENE ONTOLOGYGO:0008611 Pubmed10553003 Pubmed11275267 Reactome Database ID Release 4375896 Reactome, http://www.reactome.org ReactomeREACT_1407 Reviewed: Jassal, B, 2009-02-27 15:21:18 Synthesis of lysophosphatidic acid from dihydroxyacetone phosphate