Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) Release of CSK from SRC Authored: Garapati, P V, 2008-06-16 17:13:06 CSK bound to integrin alphaIIb beta3 negatively regulates SRC by phosphorylating the Tyr-530. Platelet adhesion to fibrinogen causes the disassociation of CSK from alphaIIb beta3 complex. Edited: Garapati, P V, 2008-06-16 17:13:06 Pubmed11940607 Pubmed16005629 Pubmed1722201 Reactome Database ID Release 43377644 Reactome, http://www.reactome.org ReactomeREACT_15349 Reviewed: Shattil, SJ, 2008-09-16 06:21:39 has a Stoichiometric coefficient of 2