PathwayStep1097 PathwayStep1094 PathwayStep1095 PathwayStep1096 Dermatan sulfate biosynthesis Authored: Jassal, B, 2011-12-01 Dermatan sulfate (DS) consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. As with CS, GalNAc residues can be sulfated in CS chains but also the uronic acid <br>residues may be substituted with sulfate at the 2- and 4- positions. The steps below outline the synthesis of a simple DS chain (Silbert & Sugumaran 2002). Edited: Jassal, B, 2011-12-01 GENE ONTOLOGYGO:0030208 Pubmed12512856 Reactome Database ID Release 432022923 Reactome, http://www.reactome.org ReactomeREACT_120800 Reviewed: D'Eustachio, P, 2012-03-28 DSPGs are secreted GalNAc is sulfated on position 4 once dermatan sulfate is formed Dermatan sulfate can be further sulfated on position 2 of iduronate Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)