PathwayStep1090 PathwayStep1091 PathwayStep1092 PathwayStep1088 PathwayStep1089 PathwayStep1086 PathwayStep1087 Chondroitin sulfate biosynthesis Authored: Jassal, B, 2011-12-01 Chondroitin sulfate (CS) glycosaminoglycan <br>consists of N-acetylgalactosamine (GalNAc) residues <br>alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying degrees on 4- and/or 6- positions. The steps below describe the biosynthesis of a simple CS molecule (Pavao et al. 2006, Silbert & Sugumaran 2002). Edited: Jassal, B, 2011-12-01 GENE ONTOLOGYGO:0030206 Pubmed12512856 Pubmed17239764 Reactome Database ID Release 432022870 Reactome, http://www.reactome.org ReactomeREACT_120989 Reviewed: D'Eustachio, P, 2012-03-28 The addition of GalNAc to the terminal glucuronate residue forms chondroitin A glucuronate moiety is added to chondroitin GalNAc is added to chondroitin CSPG is secreted Chondroitin can be sulfated on position 6 of GalNAc by CHST3,7 Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15 Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13