FADK1 bound p130Cas complex Phosphorylated p130Cas in complex with FADK1 Phosphorylation of p130Cas by SRC-FADK1 complex Authored: Garapati, P V, 2008-06-16 17:13:06 Edited: Garapati, P V, 2008-06-16 17:13:06 Pubmed12585966 Pubmed12640026 Pubmed16581250 Reactome Database ID Release 43372693 Reactome, http://www.reactome.org ReactomeREACT_15375 Reviewed: Shattil, SJ, 2008-09-16 06:21:39 SH3-mediated binding of p130Cas to FAK is linked to enhanced tyrosine phosphorylation of p130Cas at multiple sites. The Cas substrate domain contains 15 separate YxxP motifs after phosphorylation recruits the SH2 mediated binding of Crk adaptor protein that affect the downstream MAPK signalling pathway, resulting in cell survival and increased motility.