Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 FADK1 bound p130Cas complex Recruitment of p130Cas to FADK1 Authored: Garapati, P V, 2008-06-16 17:13:06 Edited: Garapati, P V, 2008-06-16 17:13:06 Pubmed16581250 Pubmed16919435 Reactome Database ID Release 43372705 Reactome, http://www.reactome.org ReactomeREACT_15348 Reviewed: Shattil, SJ, 2008-09-16 06:21:39 p130Cas (Crk-associated substrate) is an adaptor protein that promotes protein-protein interactions, leading to the multiprotein complexes. The interaction of p130Cas with other proteins modulates cell motility, survial and proliferation. P130Cas is one of the main phosphorylation targets of the FAK/Src complex. The p130Cas SH3 domain binds to PR1 and PR2 (‘PxxP’) domains in the FAK C-terminal domain.