Integrin alphaIIb beta3 Integrin alpha IIb p(T779)-beta 3 Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding Authored: Akkerman, JW, 2009-09-04 EC Number: 2.7.11 Edited: Jupe, S, 2010-09-01 Pubmed10896934 Reactome Database ID Release 43432110 Reactome, http://www.reactome.org ReactomeREACT_24004 Reviewed: Heemskerk, JW, 2010-09-01 The binding of SHC to integrin alpha IIb beta 3 is blocked by phosphorylation of beta 3 at Thr-779, or by substitution of this residue for Asp. PDK1 and Akt1/PKB-alpha both specifically target Thr-779 in in vitro assays.