Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active (p-Y419)-SRC:p(Y397)-FADK1 Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p(Y397,407,576,577,861,925)-FADK1 Phosphorylation of pFADK1 by SRC Authored: Garapati, P V, 2008-06-16 17:13:06 Edited: Garapati, P V, 2008-06-16 17:13:06 Pubmed11476890 Pubmed16919435 Reactome Database ID Release 43354124 Reactome, http://www.reactome.org ReactomeREACT_15368 Reviewed: Shattil, SJ, 2008-09-16 06:21:39 The recruitment of FADK1 to active SRC leads to the efficient tyrosine phosphorylation of multiple additional sites on FADK1. SRC trans-phosphorylates FADK1 within the kinase doman activation loop (Y576 and Y577) and within the FADK1 C-terminal domain (Y861 and Y925). has a Stoichiometric coefficient of 5