Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) Dephosphorylation of inactive SRC by PTPB1 Authored: Garapati, P V, 2008-06-16 17:13:06 EC Number: 3.1.3.48 Edited: Garapati, P V, 2008-06-16 17:13:06 Pubmed16005629 Pubmed16115959 Pubmed7532003 Reactome Database ID Release 43377643 Reactome, http://www.reactome.org ReactomeREACT_15464 Reviewed: Shattil, SJ, 2008-09-16 06:21:39 The integrin alphaIIb beta3:Inactive SRC complex recruits PTP1B protein tyrosine phosphatase resulting in the dephosphorylation of SRC tyrosine 530. The phosphorylated tail of SRC tail interacts with the SH2 domain thereby repressing kinase activity; removal of phosphorylation activates SRC kinase activity. has a Stoichiometric coefficient of 2