Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:FADK1 Translocation of FADK1 to Focal complexes As integrins do not have an intrinsic catalytic activity, the signals initiated by the ECM-integrin interactions are transduced into cells through the integrin bound protein-tyrosine kinases. Focal adhesion kinase 1 (FADK1, FAK) is one of the protein tyrosine kinases that plays a prominent role in integrin signaling. FAK has been implicated in controlling cell motility and transmitting a cell survival signal from ECM. <br><br>FAK is recruited to sites of integrin clustering by directly binding to integrin associated c-Src.<br> Authored: Garapati, P V, 2008-06-16 17:13:06 Edited: Garapati, P V, 2008-06-16 17:13:06 Pubmed11476890 Pubmed16005629 Pubmed16919435 Reactome Database ID Release 43354066 Reactome, http://www.reactome.org ReactomeREACT_15371 Reviewed: Shattil, SJ, 2008-09-16 06:21:39