Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK SYK activation by SRC Authored: Akkerman, JW, 2009-06-03 EC Number: 2.7.10 Edited: Jupe, S, 2010-09-01 Pubmed7513017 Pubmed7961845 Pubmed9351824 Reactome Database ID Release 43429441 Reactome, http://www.reactome.org ReactomeREACT_23775 Reviewed: Heemskerk, JW, 2010-09-01 SYK activation in integrin signalling is associated with increased tyrosine phosphorylation. SYK activation and phosphorylation of SYK targets can be blocked by SRC inhibitors or expression of dominant negative SRC mutants. has a Stoichiometric coefficient of 2