Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC) Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK SYK binds to integrin alphaIIb beta3 Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2010-09-01 Integrin alphaIIb beta3 'outside-in' signalling involves multiple proteins including SRC, SYK, SLP-76 and PLCgamma2. SRC is constitutively associated with the C-terminal tail of integrin beta 3. SYK is recruited to the beta3 tail and subsequently activated by SRC. Pubmed11940607 Pubmed12171941 Pubmed15205259 Pubmed17055557 Pubmed9351824 Reactome Database ID Release 43429415 Reactome, http://www.reactome.org ReactomeREACT_23931 Reviewed: Heemskerk, JW, 2010-09-01 has a Stoichiometric coefficient of 2