Integrin alphaIIb beta3:p(Y530)-SRC:CSK:Talin:RIAM complex Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC Activated integrin alphaIIb beta3 binds SHC1 Authored: Akkerman, JW, 2009-09-04 Edited: Jupe, S, 2010-09-01 Pubmed10548108 Pubmed10964917 Pubmed8631894 Reactome Database ID Release 43432096 Reactome, http://www.reactome.org ReactomeREACT_23801 Reviewed: Heemskerk, JW, 2010-09-01 The beta 3 integrin cytoplasmic tail binds SH2-containing protein (SHC), an adapter in Ras signaling. Phosphorylation of Y785 may be necessary for binding; phosphorylation of T779 inhibits SHC binding. Mice expressing a mutated beta 3 where Y773 and Y785 have been mutated to F exhibit rebleeding from tail wounds and subtle defects in clot retraction and platelet aggregation.