PathwayStep1189 PathwayStep1184 PathwayStep1183 PathwayStep1182 PathwayStep1181 PathwayStep1188 PathwayStep1187 PathwayStep1186 PathwayStep1185 PathwayStep1180 Synthesis of IP2, IP, and Ins in the cytosol Authored: Williams, MG, 2011-10-28 Edited: Williams, MG, 2011-10-28 GENE ONTOLOGYGO:0043647 Inositol phosphates IP2, IP and the six-carbon cyclic alcohol inositol (Ins) are produced by various phosphatases and the inositol-3-phosphate synthase 1 (ISYNA1) (Ju et al. 2004, Ohnishi et al. 2007, Irvine & Schell 2001, Bunney & Katan 2010). Pubmed11331907 Pubmed15024000 Pubmed17068342 Pubmed20414202 Reactome Database ID Release 431855183 Reactome, http://www.reactome.org ReactomeREACT_150352 Reviewed: Challiss, John, 2012-11-09 Reviewed: Wundenberg, Torsten, 2012-11-06 Glc6P is isomerised to I3P by ISYNA1 in the cytosol I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol