Activated conventional protein kinase C Protein Kinase C, conventional Activation of conventional Protein Kinase C Pubmed19033211 Pubmed9601053 Pubmed9814702 Reactome Database ID Release 43114553 Reactome, http://www.reactome.org ReactomeREACT_286 The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling.