DAG kinase produces phosphatidic acid from DAG Authored: Jupe, S, 2009-06-11 Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol. EC Number: 2.7.1.107 Edited: Jupe, S, 2009-09-09 Pubmed11080611 Pubmed18062770 Pubmed2175712 Pubmed8626548 Reactome Database ID Release 43426240 Reactome, http://www.reactome.org ReactomeREACT_19402 Reviewed: Akkerman, JW, 2009-09-04