PathwayStep1132 PathwayStep1133 PathwayStep1130 PathwayStep1131 PathwayStep1129 PathwayStep1138 PathwayStep1135 PathwayStep1134 PathwayStep1137 PathwayStep1136 Synthesis of IPs in the nucleus Authored: Williams, MG, 2011-10-28 Edited: Williams, MG, 2011-10-28 GENE ONTOLOGYGO:0043647 Pubmed10827188 Pubmed11331907 Pubmed11502751 Pubmed12027805 Pubmed12223481 Pubmed16293229 Pubmed16781889 Pubmed17412958 Pubmed17943301 Pubmed18355727 Pubmed20359876 Reactome Database ID Release 431855191 Reactome, http://www.reactome.org ReactomeREACT_150275 Reviewed: Challiss, John, 2012-11-09 Reviewed: Wundenberg, Torsten, 2012-11-06 Within the nucleus, inositol polyphosphate multikinase (IPMK), inositol-pentakisphosphate 2-kinase (IPPK), inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) produce IP5, IP6, IP7, and IP8 inositol phosphate molecules (Irvine & Schell 2001, Alcazar-Romain & Wente 2008, York 2006, Monserrate and York 2010, Nalaskowski et al. 2002, Chang et al. 2002, Chang & Majerus 2006, Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008, Mulugu et al. 2007). 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus