PathwayStep1158 PathwayStep1159 PathwayStep1156 PathwayStep1157 PathwayStep1154 PathwayStep1155 PathwayStep1152 PathwayStep1153 PathwayStep1150 PathwayStep1151 PathwayStep1149 PathwayStep1148 PathwayStep1147 PathwayStep1146 PathwayStep1145 Synthesis of pyrophosphates in the cytosol Authored: Williams, MG, 2011-10-28 Edited: Williams, MG, 2011-10-28 GENE ONTOLOGYGO:0043647 Inositol phosphates such as IP4, IP5 and IP6 are converted to an even wider variety of IPs including the di- and triphospho inositol phosphates, also known as pyrophosphates (Irvine & Schell 2001, Alcazar-Romain & Wente 2008, York 2006, Monserrate and York 2010, Ho et al. 2002, Saiardi et al. 2001, Draskovic et al. 2008, Choi et al. 2007, Caffrey et al. 2000, Leslie et al. 2002). Pubmed10777568 Pubmed11331907 Pubmed11502751 Pubmed11909533 Pubmed12121577 Pubmed16781889 Pubmed17702752 Pubmed17943301 Pubmed18355727 Pubmed20359876 Reactome Database ID Release 431855167 Reactome, http://www.reactome.org ReactomeREACT_150188 Reviewed: Challiss, John, 2012-11-09 Reviewed: Wundenberg, Torsten, 2012-11-06 (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol