PathwayStep1120 PathwayStep1121 PathwayStep1122 PathwayStep1113 PathwayStep1112 PathwayStep1115 PathwayStep1114 PathwayStep1117 PathwayStep1116 PathwayStep1119 PathwayStep1118 PathwayStep1123 Synthesis of IP3 and IP4 in the cytosol An array of inositol trisphosphate (IP3) and tetrakisphosphate (IP4) molecules are synthesised by the action of various kinases and phosphatases in the cytosol (Irvine & Schell 2001, Bunney & Katan 2010). Authored: Williams, MG, 2011-10-28 Edited: Williams, MG, 2011-10-28 GENE ONTOLOGYGO:0043647 Pubmed11331907 Pubmed20414202 Reactome Database ID Release 431855204 Reactome, http://www.reactome.org ReactomeREACT_150312 Reviewed: Challiss, John, 2012-11-09 I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by PLCD4 at the ER membrane I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol