Expression of Fatty Acid Synthase (FASN) 'SREBP1A/1C:NF-Y:SP1:FASN gene [nucleoplasm]' positively regulates 'Expression of Fatty Acid Synthase (FASN)' ACTIVATION Pubmed10207099 Pubmed10535992 Pubmed10585467 Pubmed10759542 Pubmed11994399 Pubmed12177166 Pubmed17197698 Pubmed18559965 Pubmed18682402 Pubmed7592729 Pubmed8833906 Pubmed8955100 Pubmed9786926 Reactome Database ID Release 431655857 Reactome, http://www.reactome.org ReactomeREACT_118058 SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of the fatty acid synthase gene (FASN) and enhance transcription (Bennett et al. 1995, Magana and Osborne 1996, Shimano et al. 1996, Boizard et al. 1998, Foretz et al. 1999, Shimano et al. 1999, Amemiya-Kudo et al. 2002, Griffin et al. 2007, Choi et al. 2008, Rome et al. 2008, reviewed in Horton et al. 2002). The enhancer activity of SREBF1 requires simultaneous binding of NF-Y and SP1 to the promoter (Xiong et al. 2000). SREBP1A/1C:NF-Y:SP1:FASN gene