G-protein beta-gamma complex G-protein alpha (13):GTP TP receptor:Thromboxane A2:G-protein G13 (active) Dissociation of the TP:G13 complex Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2009-11-03 Pubmed18577758 Pubmed8736705 Reactome Database ID Release 43428918 Reactome, http://www.reactome.org ReactomeREACT_20559 Reviewed: Harper, MT, 2009-11-02 Reviewed: Jones, ML, 2009-11-02 Reviewed: Poole, AW, 2009-11-02 The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).