PathwayStep2534 PathwayStep2533 PathwayStep2532 PathwayStep2531 PathwayStep2530 PathwayStep2529 PathwayStep2528 Methionine salvage pathway Authored: Stephan, R, 2010-10-24 Edited: Jassal, B, 2011-03-30 GENE ONTOLOGYGO:0019509 Methionine salvage is a sequential pathway of six reactions that create methionine from 5'-methylthioadenosine (MTA) which is a byproduct of polyamine biosynthesis in nearly all organisms. The process happens completely in the cytosol. It is important in humans for recycling of sulphur that has to be assimilated using energy. (Pirkov et al, 2008; Albers, 2009) Pubmed18625006 Pubmed19946895 Reactome Database ID Release 431237112 Reactome, http://www.reactome.org ReactomeREACT_75881 Reviewed: D'Eustachio, P, 2011-05-23 MTA is cleaved and phosphorylated Methylthio-ribulose-P = Methylthio-ribose-P Methylthio-ribose-P = Methylthio-ribulose-P Acireductone is created Dehydration of methylthio-ribulose-P Transamination of MOB to methionine Acireductone is oxidized to MOB