PathwayStep2482 PathwayStep2481 PathwayStep2480 PathwayStep2486 PathwayStep2485 PathwayStep2484 PathwayStep2483 PathwayStep2478 PathwayStep2479 PathwayStep2477 PathwayStep2489 PathwayStep2488 PathwayStep2487 PathwayStep2490 Tryptophan catabolism Authored: D'Eustachio, P, 2005-07-20 13:46:37 Edited: D'Eustachio, P, 2005-07-20 13:46:37 GENE ONTOLOGYGO:0006569 Pubmed1772073 Reactome Database ID Release 4371240 Reactome, http://www.reactome.org ReactomeREACT_916 Tryptophan is catabolized in seven steps to yield aminomuconate. Intermedistes in this process are used as well for the synthesis of serotonin and kynurenine (Peters 1991). 2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2 2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [mitochondrial] N-formylkynurenine + H2O => kynurenine + formate kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL1] tryptophan + O2 => N-formylkynurenine [IDO] tryptophan + O2 => N-formylkynurenine [IDO2] tryptophan + O2 => N-formylkynurenine [TDO] 3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2] 4-(2-aminophenyl)-2,4-dioxobutanoate => kynurenate + H2O [cytosolic]