PathwayStep2513 PathwayStep2514 Agmatine biosynthesis Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine. Agmatine binds to several target receptors in the brain and has been proposed as a novel neuromodulator (Reghunathan 2006). Agmatine has the potential to serve in the coordination of the early and repair phase pathways of arginine in inflammation (Satriano, 2003). Authored: Gopinathrao, G, 2008-05-21 17:26:32 Edited: Gopinathrao, G, 2006-04-27 13:13:48 GENE ONTOLOGYGO:0097055 Pubmed15028567 Pubmed15028568 Pubmed15784477 Pubmed17025265 Reactome Database ID Release 43351143 Reactome, http://www.reactome.org ReactomeREACT_14800 Reviewed: D'Eustachio, P, 2008-06-12 14:43:38 Agmatine + H2O <=> putrescine + urea Arginine<=>Agmatine+CO2