GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen I:p-SYK(Y348) GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen I:SYK Syk autophosphorylates Authored: Akkerman, JW, 2009-09-04 Binding of Syk causes conformational changes that lead to Syk activation by autophosphorylation. Syk can be activated by a number of phosphorylation events, and it has been proposed that Syk may function as a switch whereby any of several possible stimuli trigger the acquisition of similar activated conformations. (Tsang et al. 2008). These phosphorylations both modulate Syk's catalytic activity (Keshvara et al. 1997) and generate docking sites for SH2 domain-containing proteins, such as c-Cbl, PLC, and Vav1. EC Number: 2.7.10.2 Edited: Jupe, S, 2010-06-07 Pubmed11481033 Pubmed1874735 Pubmed18818202 Pubmed19409513 Pubmed9099676 Reactome Database ID Release 43453200 Reactome, http://www.reactome.org ReactomeREACT_23800 Reviewed: Kunapuli, SP, 2010-06-07