Activated PAR1:Beta-arrestin-1:Activated Src:Activated ERK Activated PAR1:Beta-arrestin-1:Activated Src:ERK Activated Src activates ERK Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2010-06-07 Pubmed16580177 Pubmed9228083 Reactome Database ID Release 43418163 Reactome, http://www.reactome.org ReactomeREACT_23900 Reviewed: Kunapuli, SP, 2010-06-07 Within the beta-arrestin-1:Src:ERK complex, activated Src phosphorylates and activates ERK. ERK activation requires dual Thr and Tyr phosphorylations, at Thr202/Tyr204 for human ERK1 and Thr185/Tyr187 for human ERK2. Significant ERK activation requires phosphorylation at both sites, with Tyr phosphorylation preceding that of Thr. This reaction is given as a black-box event because the phosphorylation state of ERK on binding to beta-arrestin-1 is unknown.