PathwayStep2473 PathwayStep2475 PathwayStep2474 Proline catabolism Authored: D'Eustachio, P, 2003-06-24 00:00:00 Edited: D'Eustachio, P, 2003-06-24 00:00:00 GENE ONTOLOGYGO:0006562 ISBN0079130356 Proline is catabolized in two steps to yield L-glutamate gamma-semialdehyde, which can react further with glutamate to yield ornithine and alpha-ketoglutarate (annotated as a reaction of amino acid synthesis and interconversion) or with NAD+ to yield glutamate and NADH + H+ (Phang et al. 2001). Reactome Database ID Release 4370688 Reactome, http://www.reactome.org ReactomeREACT_1002 L-1-pyrroline-5-carboxylate <=> L-glutamate gamma-semialdehyde L-glutamate gamma-semialdehyde + NAD+ => glutamate + NADH + H+ proline => L-1-pyrroline-5-carboxylate