PathwayStep2422 PathwayStep2421 PathwayStep2423 Serine biosynthesis Authored: Stephan, R, 2010-10-16 Edited: Jassal, B, 2010-10-18 GENE ONTOLOGYGO:0006564 L-Serine is needed in human brain in large amounts as precursor to important biomolecules such as nucleotides, phospholipids and the neurotransmitters glycine and D-serine. The pathway for its synthesis starts with 3-phosphoglycerate and it later needs glutamate as an amination agent. Deficiencies in the participating enzymes lead to severe neurological symptoms that are treatable with serine if treatment starts early (de Koning & Klomp 2004). Pubmed15021249 Reactome Database ID Release 43977347 Reactome, http://www.reactome.org ReactomeREACT_115789 Reviewed: D'Eustachio, P, 2011-10-26 phosphoserine is dephosphorylated 3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate 3-phosphoglycerate is dehydrogenated