2-amino 3-carboxymuconate semialdehyde transforms non-enzymatically to quinolinate Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT1] A phospho-ribosyl group is added to quinolinate Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT2] Nicotinate D-ribonucleotide + ATP => deamino-NAD+ + pyrophosphate [NMNAT3] Amidation of deamino-NAD+ to NAD+ NAD+ is phosphorylated to NADP+ PathwayStep2369 PathwayStep2368 PathwayStep2367 PathwayStep2366 PathwayStep2370 PathwayStep2374 PathwayStep2365 PathwayStep2364 Nicotinamide salvaging Nicotinate metabolism GENE ONTOLOGYGO:0019674 Nicotinate (niacin) and nicotinamide are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP+). When NAD+ and NADP+ are interchanged in a reaction with their reduced forms, NADH and NADPH respectively, they are important cofactors in several hundred redox reactions. Nicotinate is synthesized from 2-amino-3-carboxymuconate semialdehyde, an intermediate in the catabolism of the essential amino acid tryptophan. Pubmed14704851 Reactome Database ID Release 43196807 Reactome, http://www.reactome.org ReactomeREACT_11088