Adenylation of phosphopantetheine Phosphorylation of dephospho-CoA to produce CoA CoA transport across the inner mitochondrial membrane Pantothenate is phosphorylated [PANK2] Condensation of phosphopantothenate with cysteine Pantothenate is phosphorylated [PANK1;3;4] Phosphopantothenoylcysteine is decarboxylated PathwayStep2346 PathwayStep2347 PathwayStep2348 PathwayStep2349 PathwayStep2350 PathwayStep2352 PathwayStep2351 Coenzyme A biosynthesis Authored: Jassal, B, 2007-04-24 08:38:46 Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001). GENE ONTOLOGYGO:0009108 Pubmed11158296 Pubmed11923312 Pubmed13032008 Pubmed15893380 Pubmed2981478 Reactome Database ID Release 43196783 Reactome, http://www.reactome.org ReactomeREACT_11218