Src activation following P2Y purinoceptor activation Activation of Src lies selectively downstream of P2Y1, but not P2Y12. The precise mechanism is not known, but Src regulation of the PI3K component of the intracellular calcium response downstream of P2Y12 represents a point of reciprocal cross-talk between P2Y1 and P2Y12 receptors. Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2009-11-03 Pubmed15187029 Reactome Database ID Release 43418662 Reactome, http://www.reactome.org ReactomeREACT_20585 Reviewed: Harper, MT, 2009-11-02 Reviewed: Jones, ML, 2009-11-02 Reviewed: Poole, AW, 2009-11-02