P2Y purinoceptor 1 activates MAP kinase p38 alpha ADP activates human platelets and induces endothelial cell migration. These effects are partly mediated by the P2Y1 purinocetor, inducing p38 MAP kinase activation via an uncharacterised factor. Possible mechanisms include flotillin-mediated stimulation of SRC family kinases in lipid rafts (Sugawara et al. 2007). Authored: Akkerman, JW, 2009-06-03 EC Number: 3.6.5.1 EC Number: 3.6.5.2 EC Number: 3.6.5.3 EC Number: 3.6.5.4 Edited: Jupe, S, 2009-11-03 Pubmed10759852 Pubmed17307333 Pubmed18174464 Reactome Database ID Release 43428941 Reactome, http://www.reactome.org ReactomeREACT_20632 Reviewed: Harper, MT, 2009-11-02 Reviewed: Jones, ML, 2009-11-02 Reviewed: Poole, AW, 2009-11-02 has a Stoichiometric coefficient of 2