Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP 8-oxo-GDP + H2O => 8-oxo-GMP + Pi NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP dIDP + H2O => dIMP + Pi NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP IDP + H2O => IMP + Pi PathwayStep2319 PathwayStep2318 PathwayStep2317 PathwayStep2316 PathwayStep2315 PathwayStep2320 PathwayStep2321 PathwayStep2326 PathwayStep2322 PathwayStep2323 PathwayStep2324 PathwayStep2325 Phosphate bond hydrolysis by NUDT proteins Authored: D'Eustachio, P, 2012-07-06 Edited: D'Eustachio, P, 2012-07-06 Enzymes that belong to the NUDT (Nudix) superfamily catalyze the hydrolysis of phosphodiester bonds in molecules including nucleoside triphosphates and diphosphates and nucleotide sugars. Family members are defined by the presence of an amino acid sequence motif shared with the E. coli MutT gene product, and are involved in diverse physiological processes (Mildvan et al. 2005; McLennan 2006). The hydrolysis of nucleoside di and triphosphates whose purine bases have been oxidized or deaminated may protect the cell from the mutational damage that would occur if modified deoxyribonucleotides were incorporated into DNA and from the aberrant protein synthesis that would occur if modified ribonucleotides were incorporated into mRNA (Iyama et al. 2010; Takagi et al. 2012). The hydrolysis of ADP ribose may prevent the aberrant spontaneous ADP ribosylation of cellular proteins that could occur were this molecule to accumulate to high levels in the cell (Perraud et al. 2003; Shen et al. 2003). GENE ONTOLOGYGO:0034656 Pubmed12427752 Pubmed12948489 Pubmed15581572 Pubmed16378245 Pubmed20385596 Pubmed22556419 Reactome Database ID Release 432393930 Reactome, http://www.reactome.org ReactomeREACT_150237 Reviewed: Ito, Riyoko, 2012-10-05